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In the 1800s, Jarisch-Herxheimer reactions were first described by Adolf Jarisch in medical literature after he noticed a worsening of skin lesions in a patient who had begun treatment for syphilis

167 Low- and very-low-protein diets

In their family-based study, relatives of people with BP-II had a higher risk of also having BP-II, suggesting it tends to run specifically in families (Heun and Maier, 1993)