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The generation of lipid peroxides is closely linked to intracellular iron levels, with excessive iron accumulation driving the production of ROS through the Fenton reaction, which, in turn, exacerbates lipid peroxidation ( Figure 1 )

[PubMed: 32773602] (Among 27 patients with fibromyalgia treated in a cross over trial of 5 week courses of ALA [600 mg daily] or placebo, symptoms of fibromyalgia and quality of life were similar in both treatment groups, as were adverse event rates)

Neurotransmitters such as dopamine, acetylcholine, serotonin, and some neuroactive chemicals such as short-chain fatty acids (SCFAs), can communicate with the brain via endocrine system (55)

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1 Rutin exhibits antioxidant and anti-inflammatory actions, and it aids in collagen production, thus promoting the health of the connective tissues throughout the body