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Excessive unbuffered ROS levels damage mitochondria, leading to less ATP and more ROS production, which creates a potential third self-sustained inflammatory loop

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For example, intratracheal injection of NiO NPs in mice can increase levels of pro-inflammatory cytokines, neutrophils, and bronchoalveolar lavage proteins, as well as induce apoptosis and iron accumulation in lung tissue [86].Research has also shown that NiO NPs cause neutrophil and lymphocyte inflammatory responses in rat lungs

Correct volume status, acid-base balance and electrolyte deficits as appropriate

& Ludwig-Mueller, J