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Z.LyuY.FangL

doi:10.1016/S0140-6736(23)01053-X PubMed: This trial evaluated retatrutide in 281 participants with type 2 diabetes, showing up to 16.94% weight loss and significant HbA1c reductions with favorable safety profile comparable to other GLP-1 based therapies

Regulatory cells are deficient

For example, similar to tumor cells, CAFs have a glycolytic phenotype and secrete lactic acid, which not only serves as an energy source for tumor cells and contributes to the formation of an acidic environment that suppresses immune cell function[24]