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Glutathione peroxidase 1 (Gpx1) is first identified as a selenium-dependent enzyme in 1973 and has a role as antioxidant enzyme

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Valenta R, Niederberger V

Abbreviations ABT: Aminobenzotriazole ALT: Alanine transaminase APAP: Acetaminophen AST: Aspartate transaminase BUN: Blood urea nitrogen CYPs: Cytochrome P450 CCl 4 : Carbon tetrachloride CLF: Cholyl-lysyl-fluorescein KIM-1: Kidney injury molecule-1 NGAL: Neutrophil gelatinase-associated lipocalin TMRE: Tetramethylrhodamine-ethyl ester OTA: Ochratoxin A References Atroshi F, Biese I, Saloniemi H et al (2000) Significance of apoptosis and its relationship to antioxidants after ochratoxin A administration in mice

These medications help keep urine calcium concentrations from rising by reducing bone breakdown and calcium loss (Bianchi 2010)