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Studies have found that berberine attenuates ischemia-reperfusion injury through NF-B nuclear translocation in mice with transient cerebral artery occlusion, however, this neuroprotective effect was more pronounced at the high dose (50 mg/kg) than the low dose (25 mg/kg) (Zhu et al., 2018)

If hepatic coma is not documented, then a query should be issued.

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Evidence of propofol's toxicity in humans comes from a phenomenon known as "propofol infusion syndrome" (PRIS)