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Consequently, there is a general consensus within the industry that establishing a unified risk classification framework, clarifying the regulatory positioning of EV-based products, and promoting the development of internationally accepted quality standards and testing methods are key to advancing the standardization and clinical application of EV-based therapies

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these are listed in Table 3

Particular emphasis is given to clinically relevant aspects such as the latest molecular genetic advances in WD, our improved understanding of the clinical presentation, diagnostic guidelines and an up-to-date discussion of the complicated treatment issues in this disorder