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Cancer 25: 279305 Cohen AL, Holmen SL, Colman H (2013) IDH1 and IDH2 mutations in gliomas

Multi-omics results show that ALOX15 is the main mediator of phospholipid peroxidation, acting as an ignition point during the ischemia stage, igniting phospholipid oxidation and promoting cell ferroptosis

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We hypothesize that 1) ibuprofen will decrease snail growth, movement, and reproduction by affecting energy allocation due to oxidative stress and neurotoxicity, 2) microplastic exposure will impair metabolic processes (i.e., digestion through physical blockage), reducing growth, movement, and reproduction, and 3) combined exposure will have a greater negative effect on these endpoints than ibuprofen or microplastics alone

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