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Despite being a non-invasive and quantitative method, studies have shown significant limitations in its use [28]

Women who were pregnant, lactating, or had not adhered to adequate contraception from at least 30 days prior to the study entry and did not plan to for 1 month after the final supplementation were also excluded

This would exclude the possible nonspecific contribution of the additional volume (as it may be the infusion into the anterior chamber to increase intraocular pressure above systolic pressure to induce ischemia ( Finally, the obtained findings should be summarized with the previous eye evidence

doi: 10.1007/978-1-4939-1661-0_1 19 ChrissobolisS.FaraciF