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NDI1 overexpression has been shown to rescue CI deficiency and limit the effects of mitochondrial dysfunction 48

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3.3 DARA treatment lowers ADO and elevates INO to concentrations within the receptor-activating range in MM patients To determine whether the in vitro findings translate to the clinical setting, we next quantified ADO and INO levels in paired BM and PB samples collected from 7 MM patients treated with DARA monotherapy ( Table 1 )

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10.1038/s41401-021-00726-0 28 LiY.de HaarC.ChenM.DeuringJ.GerritsM