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A key contribution of our study is the methodology for calculating nicotine equivalence, which facilitates accurate NRT dosing and supports clinical decision-making in the management of nicotine addiction

Overall, these findings demonstrate that chronic smoke exposure promotes the development of a stress-resistant adaptive state that mimics early features of carcinogenesis, characterized by acquired resistance to apoptosis and continuous activation of the NRF2 survival pathway

For clients who have difficulty with drinking, an angled or two-handled beaker or cup with a weighted base should be considered, as these can provide stability and prevent spillage if there are issues with tremors or reduced muscle control

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L.) 185194 (Oxford University Press, 1998)