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These differences help explain several characteristics that initially surprise many researchers: its distinctive orange appearance, its classification as a small molecule, its enzyme-targeted mechanism, and the style of laboratory documentation commonly supplied with it

John Diaz

No randomized controlled trials directly examine safety or efficacy of concurrent use

Other means are available for diagnosing the presence of B12 malabsorption caused by PA, the autoimmune disease that destroys the cells producing intrinsic factor

One, it may well be that levels of serum B12 in the blood gradually decrease when treatment is stopped, but still remain within the low-normal range for several months or even a few years