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Clotting times were significantly reduced during the active period (night) in nocturnal rats, with increased prothrombin (II), factor VII, and factor X during the inactive period (day) (Soulban and Labrecque, 1989)

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FIGURE 8 Gene ontology and Kyoto encyclopedia of genes and genomes enrichment analysis Gene Ontology enrichment analysis and KEGG pathway enrichment analysis were performed using David on the intersecting targets, and 235 MFs entries were screened out, the 20 closely related MFs are shown in Figure 9A, Including (GO:0005515) protein binding, (GO:0042802) identical protein binding, (GO:0005524) ATP binding, (GO:0042803) protein homodimerization activity, (GO:0019899) enzyme binding, (GO:0004672) protein kinase activity, (GO:0004674) protein serine/threonine kinase activity, (GO:0008270) zinc ion binding, (GO:0019901) protein kinase binding al

Moreover, Propolis group revealed high statistically significant microleakage values in the occlusal margin while the gingival margin showed less microleakage values