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10.1002/jcp.28961 J

Thromboinflammation: challenges of therapeutically targeting coagulation and other host defense mechanisms

Overall, these findings strongly suggest that the interaction between PGC-1 and NXF1 plays an important role in the nuclear export of mRNA, and inhibiting PGC-1 weakens the functional interaction of this relationship (Fig

Potential therapeutic targets are low-grade systemic inflammation, oxidative stress, NO signaling, RAAS signaling, ECM remodeling, calcification, VSMCs, and cellular senescence