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The translational gap between preclinical findings and clinical outcomes underscores the need for more rigorous study designs that account for bioavailability, participant heterogeneity, and methodological inconsistencies

Lei XW, Li Q, Zhang JZ, Zhang YM, Liu Y, Yang KH

She was an avid reader, particularly drawn to science, technology, and astronomy

Bathing: use a cast cover or heavy-duty trash bag sealed above the boot

There have been efforts to overcome these problems by modifying the drugs in different ways to circumvent these hindrance such as (1) isolate human native enzymes to reduce allergy, (2) isolate enzyme isoforms with higher specificities and efficiencies, (3) pegylate the enzymes to reduce allergy and prolong the half-lives, and (4) design drug combinations protocols to enhance the efficacy of chemotherapy by drug synergy and minimizing resistance