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Although little is known, it was demonstrated that zinc(II) deficiency increased the level of NO and superoxide anion by the inhibition of the N -methyl-d-aspartate receptor (NMDAR) [45] As described on PC12 cells, NMDAR activation leads to an increase in cytoplasmic calcium levels and, thus, to increased ROS [66]

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The two are synergistic making Catosal significantly more effective for metabolic recovery than either component alone

FIGURE 9 Discussion Unfavorable environmental stimulation can alter cellular redox homeostasis, which causes the excessive generation of ROS

Sterile water preparations should be used within 24-48 hours