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In HGN, pathways such as phenylpropanoid biosynthesis, phenylalanine metabolism, isoflavonoid biosynthesis, fructose and mannose metabolism and inositol phosphate metabolisms were upregulated, while phosphonate metabolism, pyrimidine metabolism, monoterpenoid biosynthesis, glycerolipid metabolism, and amino sugar and nucleotide sugar metabolism were downregulated (Fig

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Extensive research has shown that ferroptosis plays a significant role in various cardiovascular diseases, degenerative diseases, and tumors, indicating the broad prospects for studying ferroptosis in CKD

gondii show complex response, including reactive remodelling, secretion of interleukins that reduce parasite burden 241,242 and start to produce and release kynurenic acid, which is as an endogenous antagonist of NMDA and acetylcholine receptors