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In this state, the overactivation of N-methyl-D-aspartate receptor-type channels in L-glutamate (L-glu) channels mediates a large influx of Ca 2 , leading to cellular excitotoxicity and neuronal death

2025;12(21):e2414559

At just about every step along the way the scientific significance of what had been discovered and its mechanistic basis was not understood until long after the fact

Our study showed that the intrinsic circadian clock in the renal tubule exerted control over renal metabolism by regulating several key metabolic pathways, including carnitine shuttle, -oxidation of FAs, and nicotinamide (NAM) adenine dinucleotide (NAD + ) biosynthesis

67,505 Ulefnersen (ION-363), an antisense therapy targeting the FUS gene, is currently in Phase III trials for FUS-ALS