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This is because alcohol increases the concentration of CYP2E1 in liver cells, causing APAP to be oxidized faster

Fagan C, Phelan D

subsequently proposed a cyclic immonium ion of lactyllysine in tandem mass spectrometry, confirming its sensitivity and specificity through detailed analysis of lactylproteomes and spectral libraries

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Thus, in the kidney, curcumin appears to function not only as an antioxidant but also as a metabolic regulator, protecting the energy-fragile tubular epithelium from oxidative injury and subsequent fibrotic transformation