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Reactive intermediates are either produced by reactions involving enzymes such as nicotinamide adenine dinucleotide phosphate (NADP)H [6], nitric oxide synthase, or by nonenzymatic reactions through mitochondrial electron transport chain [46], and reduced transition metals [47]

Ergothioneine concentrates in parts of your body where there are lots of free radicalsthe lens of your eye and your liver, for example, as well as sensitive tissues such as bone marrow and semen

Lunghi L, Ferretti ME, Medici S, Biondi C, Vesce F

They will also set an upper limit on the total weekly dose (for example, some experts recommend not exceeding ~300 mg per week in subcutaneous dosing without further evaluation) to minimize any risk of adverse effects

Furthermore, ANT induces an increase in oxidative stress by inhibiting important antioxidant enzymes such as GSH, CAT, and SOD [35, 36]