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Preclinical toxicology studies in animals showed no concerning findings with chronic administration, but human long-term data would strengthen confidence in extended protocols

The -glucan, lentinan, is a bioactive compound produced by the macrofungus, Lentinus edodes, and has been found to have potential in improving the side effects of broad-spectrum antibiotic consumption

1 Introduction 1.1 Mitochondrial function and dynamics Mitochondria are membrane-enclosed organelles that contain their own DNA, mitochondrial DNA (mtDNA), and generate most of the cells energy in the form of ATP, using glucose, fatty acids and amino acids as energy substrates

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