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MYCN effects on the two-step biosynthesis of GSH and GSH metabolism ( top MYCN synthetic lethal hits of GSH metabolism, false discovery rate of 0.2) (median of 2-3 siRNAs)

When the initial DNA damage caused by disulfiram is combined with the effect of PARP inhibitors blocking repair pathways, the genomic instability is drastically exacerbated, thereby exerting stronger cytotoxicity on tumor cells (76)

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In vivo and in vitro evidence for the involvement of Nrf2-antioxidant response element signaling pathway in the inflammation and oxidative stress induced by particulate matter (PM10): the effective role of gallic acid