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5.3.3 CRISPR/dCas9-VPR activates the SCN1A promoter, enhancing neuron-specific Nav1.1 expression The CRISPR/dCas9-VPR system utilizes guide RNA-directed targeting of catalytically dead Cas9 (dCas9) fused to the transcriptional activator VPR to specifically upregulate endogenous SCN1A expression from its native promoter

Oftalmologie: Oboseal ocular, miopie progresiv, afectiuni ale retinei datorate dereglrilor metabolice, irigare sangvin deficitar la nivel ocular, ambliopie datorat fumatului, atrofia nervului optic i ca aditiv n tratamentul combinat cu medicaie anticataract pentru a preveni cataracta senil (datorit efectelor asupra reglrii metabolismului celular i aprovizionrii organismului cu aminoacizi eseniali )

doi: 10.2147/NDS.S243097 27 EjtahedH-SAngooraniPSoroushA-RAtlasiRHasani-RanjbarSMortazavianAMet al