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5-Aminoimidazole-4-carboxamide-1-beta-D- ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase

The key findings from this clinical program include significant reductions in body weight and fat mass in treatment groups compared to placebo, preferential loss of abdominal and visceral adipose tissue, no changes in serum IGF-1 levels at any dose tested, no negative effects on glucose metabolism or insulin sensitivity, no significant adverse events related to metabolic or endocrine disruption, and safety profile indistinguishable from placebo for most parameters

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The 0.5 mg/mL inclusion is well below any clinical toxicity threshold and has no effect on tirzepatide's GIP or GLP-1 receptor binding