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The central hypothesis of the gut-liver axis is that translocation of luminal microbiota or microbial products (pathogen-associated molecular patterns or PAMPs) through an impaired intestinal barrier function is an early step in the pathogenesis of chronic liver disease (4)

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Dosing is typically 250-500mcg twice daily for injectable, or 500-1,000mcg daily for oral

Although supplementation may affect hunger in certain situations, increased appetite is typically due to another cause