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Its pathology involves complex interplay of protein aggregates (amyloid and tau), neuronal loss, synaptic dysfunction, vascular compromise, and chronic inflammation

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For instance, Toll-like receptors (TLR) enable host innate immune system to identify pathogen-associated molecular patterns (PAMP) of microbes, such as lipopolysaccharide (LPS), lipoproteins or flagellin [72]

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