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FLT3 inhibitor quizartinib induces the upregulation of inflammatory pathways in AML DTP cells and thereby confers susceptibility to anti-inflammatory glucocorticoids (GCs) (Gebru et al., 2020)

USA 103 , 76077612 (2006)

HIE, Neonatal hypoxic-ischemic encephalopathy

Interestingly, metazoans as a group exhibit a Met auxotrophy [135], suggesting the ability to generate Hcy from Cys was lost roughly coincident with the metazoan transition, when single-celled aquatic heterotrophic protozoans gave rise to the first primitive multicellular aquatic heterotrophic animals

Apart from the guanidinium head group, the permanent positive charge can also be delocalized in heterocyclic rings, such as pyridinium rings and imidazolium rings