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The detoxification of 4-HNE by aldo-keto reductase family 1, member C (AKR1C), and its regulation by NRF2, indicates that 4-HNE accumulation may be a key ferroptotic driver ( Thirdly, identifying molecular markers for cells undergoing ferroptosis remains challenging

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The Platyhleminthes also suffered a notable SVCTP NL loss, since this gene is only present in one out of nine species analysed (Fig

They can control multiple pathogenic variables by targeting various pathways and systems

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