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The brain is protected by the bloodbrain barrier (BBB), a selective barrier formed by the endothelial cells of the cerebral microvessels, which at the same time acts as a bottleneck for drug delivery by preventing the vast majority of drugs to reach the brain

Total bilirubin is the sum of two forms of bilirubin in the blood: direct (conjugated) bilirubin and indirect (unconjugated) bilirubin

In addition, AGEs in tissues increase the rate of free radical production to 50-times the rate of free-radical production by unglycated proteins, even further increasing the rate of the aging process

Therefore, it can be said that LAB population increases as pH reduces and finally both reach a plateau when sourdough mature [12]

Sterility tests were both performed internally using tryptic soy broth sterility test method and externally by an ISO-certified microbiology lab (MIKROLAB Stockholm AB) for independent sterility and bioburden tests