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Despite considerable progress in the research about the programmed cell death, surprisingly the intracellular cascade leading to neuronal demise in Alzheimers disease still remains incompletely elucidated

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The preclinical and clinical literature strongly support trimetazidines potential to treat bipolar depression, having anti-inflammatory and antioxidant properties while normalizing mitochondrial function only when it is compromised

The sensitivity of mPTP to Ca 2+ was evaluated by calculating the amplitude of control and Ca 2+ -dependent swelling of heart mitochondria in the studied groups of animals

The funders played no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript