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Additionally, instead of internalization, the conjugated drug may release payloads by linker cleavage within the tumor cell microenvironment (Figure 13B), killing not only target cells but also non-targeted cells nearby

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44,172,861,862 Cell-free phage synthesis has also been employed as a quality control method to compare the activity of cell extracts prepared with different methods 86 and applied as a screening and engineering platform for potential therapeutics

10.1016/S0140-6736(20)30925-9 11

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