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In a randomized, placebo-controlled phase 1 clinical trial, 14-day treatment with TLC-2716 was well tolerated (primary endpoints) and resulted in placebo-adjusted reductions up to 38.5% in plasma TG and 61% in postprandial remnant cholesterol (secondary endpoints)

(2022) 18:e1010963

Doseresponse analysis further indicated a statistically significant augmentation in mortality risk at doses above 150 IU/day (27)

In a clinical setting, participants using oral glutathione supplements showed a significant reduction in melanin levels compared to placebo groups

Elevated production of ROS in C9orf72-associated ALS is also associated with abnormalities in mitochondrial function and neuroinflammation (Briehl et al., 80 DPRs interact with Atp5a1, which compromises mitochondrial functions in mice due to increased ROS production (Choi et al., 2019)