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The acrylamide warhead on ibrutinib and zanubrutinib has a GSH half-life of 33 h, while spebrutinib warhead acyl-acrylamide has a half-life of ~1.6 h [107]

He JW, Cai G

doi: 10.3389/fimmu.2021.799558 Received 21 October 2021 Accepted 22 December 2021 Published 14 January 2022 Volume 12 - 2021 Edited by Massimo Collino, University of Turin, Italy Reviewed by Baihai Jiao, University of Connecticut Health Center, United States