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Building on this, Ward and colleagues also showed that mutation of other solvent-exposed amino acids surrounding I253 in mouse IgG1 could result in enhanced affinity at pH 6.0 towards a truncated soluble form of mouse FcRn as measured by surface plasmon resonance (SPR), resulting in increased serum persistence in WT mice [99]

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Response: We appreciate the commenter's concern about drug costs for HIV patients