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10.1126/science.284.5415.748 80 LiuY.HeY.JinA.TikunovA

By encouraging the interaction of the E3 ligase peroxin2 (PEX2) with the E2 ubiquitin-conjugating enzyme D2 (UBC4), Klotho enhances the ubiquitinated degradation of adipose triglyceride lipase (ATGL), a crucial enzyme in lipolysis and lipoautophagy