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As H 2 O 2 and superoxide (O 2 ) ions have been reported to have an inhibitory effect on SOD and catalase activities, respectively, the authors have suggested that riboflavin deficiency may lead to an overproduction of reactive oxygen species (obviously through a mechanism independent of the glutathione redox cycle) beyond the scavenging ability of SOD and catalase

Filipovic et al ., 2012)

However, the net effect of TGR5 activation within the TIME is complex and highly context-dependent

Cell viability, LDH content and intracellular ROS assays After seeding the cells in the 96-well plate for 24 h post-transfection, they were treated with AFB 1 at the concentration of 10, 25, 50, 100 and 200 g/L

M.ConradM