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Research on osteosarcoma treatment has revealed that DDRGK domain-containing protein 1 (DDRGK1) inhibits the ubiquitin-proteasome-mediated degradation of NRF2 by competitively binding to Keap1

doi: 10.1002/1529-0131(200011)43:11 3.0.Co;2-k 132 SchettGZwerinaJFiresteinG

Impaired GPX4 function is implicated in tumorigenesis, neurodegeneration, infertility, inflammation, immune disorders, and ischemia-reperfusion injury