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A healthy microbiome also supports immune function via the immune-related tissues of the intestine such as the intestinal lymph tissue

[DOI] [PMC free article] [PubMed] [Google Scholar] 272.Wang H, Zhu Y, Liu H, Liang T

Since the chromogranins activate microglia in absence of AD-neuropathology, the immune environment of the frail brain should be studied further in future, to define differences that may underlie cognitive vulnerability 77,78