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Cancer is a complex, multifactorial disease whose risk of development and progression depends on both intrinsic (oncogenic signaling, epigenetic alterations, genomic instability, and disturbed cell metabolism) and extrinsic (tissue damage, infections, and mutagenic species) factors

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doi: 10.1016/j.jpsychires.2018.08.015 94 LiYWangLHuangJZhangPZhouYTongJet al

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In this study, PLGA-PEG nanoparticles induced expression of autophagy-associated genes autophagy related 3 ( ATG3 ), DNA damage regulated autophagy modulator 2 ( dram2 ), GABA type A receptor associated protein like 2 ( GABARAPL2 ), and RAB24, member RAS oncogene family (RAB24), (Fig 5A)