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When the assessment of seminal OS becomes more standardized, this test could be important to identify those who could benefit from AOX

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Since the majority of paracetamol absorption in the gastrointestinal tract occurs within the first 4 h[40], activated charcoal is generally believed to be most beneficial if administered within that time period, as its mechanism of action is to interfere with paracetamol absorption

Through machine learning methods, three key genes (SRPK1, BIRC2, and KLHL3) were identified, and their significance was validated in other datasets and clinical patients (Huang et al., 2023)