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In addition, it appears that the level of regulation or intervention upon these responses is quite important as downstream interventions such as deletion of antioxidant genes like HO-1 result in exacerbation of atherosclerosis but a more upstream level of intervention, such as deletion of Nrf2 transcription factor, results in the opposite

& van den Berg, M

334 A phase I study is ongoing to evaluate AG-270 in advanced solid tumors and lymphomas (NCT03435250)