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Treatment with BPTES downregulated the phosphorylation of the downstream substrates p70S6K and 4E-BP1 of mTORC1 in the intestine of IL-10-/- mice and improved intestinal barrier function and Th/Treg balance to reduce the symptoms of chronic colitis in mice (92)

MS2 analysis consisted of quadrupole isolation (isolation window 0.7) of precursor ion followed by collision-induced dissociation (CID) in the ion trap (AGC 1.8E4, normalized collision energy 35%, maximum injection time 120 ms)

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One additional case of acute pancreatitis was confirmed in a patient treated with semaglutide in another clinical trial

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