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for example, lower H3K18 acetylation (H3K18Ac) is linked to improved survival in primary GBM, whereas higher H4K20 trimethylation (H4K20me3) is associated with better outcomes in secondary GBM

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While a substitution with the polar serine at position 13 retained wild-type dehydratase activity, presumably due to the alcohols ability to assume cysteines function in stabilizing deprotonated GS , the only other Pt GSTF8 variants to keep analbeit reducedflavan-3,3,4-triol ( 4 ) dehydration activity contained a glycine, alanine or asparagine mutation (Fig

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