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In Experiment 1, oocyte viability, early apoptosis, mortality, oxidative status, the mitochondrial membrane potential and distribution, DNA fragmentation, maturation, fertilization, embryo development rates, blastocyst quality and cumulus cell activity were analyzed by factorial ANOVA followed by the Bonferroni post hoc correction

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By interfering with the synthesis of purines and pyrimidines, which are critical components of DNA and RNA, Alimta prevents cancer cells from replicating and spreading, thereby leading to their death or cessation of growth