autoregulatory control of mitochondrial glutathione homeostasis

autoregulatory control of mitochondrial glutathione homeostasis in Cellular Redox and Disease Manifestation SLC25A39 identified as a key

Name: autoregulatory control of mitochondrial glutathione homeostasis in Cellular Redox and Disease Manifestation SLC25A39 identified as a key
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SLC25A39 identified as a key regulator of hepatocellular carcinoma progression through the mitochondrial ROScytochrome ccaspase signaling axis Cellular & Molecular Biology Letters Springer Nature Link glutathione and homeostasis at the Crossroads of Redox Glucose Metabolism in Diabetes Mellitus Indian Journal of Clinical Biochemistry autoregulatory control of mitochondrial glutathione Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis ScienceDirect Mitochondrial Glutathione: Regulation and Functions Gaetano Calabrese, Bruce Morgan, Jan Riemer, 2017 Mitochondrial glutathione transporter SLC25A40 regulates macrophage cytokine production Scientific Reports

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The experimental data show clear results

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In addition to the relevance of POP conjugation cited previously, hyperglycemia and hyperinsulinemia appear to directly inhibit glutathione synthesis (GCL), and the increased production of reactive oxygen species which accompanies diabetes further depletes GSH levels