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Heavy metals are also known to interfere with the functioning of metalloproteins (proteins containing metal ions as cofactors) by modifying or replacing the essential divalent ions

J Carcinog 2006;5:14

Individual SCA that were recognizable at week 4 of imaging were followed until week 19 or until their small size made them undistinguishable from the background

242 Establishing cheap and accurate point-of-care diagnostic assays for -thalassaemia and improving the availability of haemoglobin HPLC and electrophoresis to diagnose -thalassaemia are important priorities