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Moving forward, progress in this field will require integrative, multi-disciplinary approaches that leverage advanced imaging techniques, longitudinal studies, and systems-level tools such as genetics, metabolomics, and sleep phenotyping

Acknowledgements This investigation was funded in part by the National Institutes of Health through grants R01 NS055095 (RAG) and in a facility constructed with support from Research Facilities Improvement Program Grant C06 RR15482 from the National Center for Research Resources, NIH

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Incorporating analogous mitochondria directed GSH-sensing reporters into nanoplatforms would allow simultaneous readout and modulation of intramitochondrial redox status, enabling closed-loop theranostic schemes i.e

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