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While both strains increased body mass with age, body mass doubled in old relative to young WT mice

Cell type-specific activation of the cGAS-STING pathway Besides various tumor cells, STING is also expressed in other cells, including all APCs, endothelial cells (ECs), MDSCs, T cells, NK cells and B cells (Fig

Mitochondrial complex defects (e.g., Cox10 deficiency) inhibit pyruvate-to-acetyl-CoA conversion, upregulate PDK4, and thereby block glucose metabolism and exacerbate lipid accumulation, forming a vicious cycle [151]

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