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Regulation: MTRR activity is regulated by factors such as cellular redox status and availability of NADPH, which serve as cofactors for MTRR-mediated reduction of MAT

Autoimmun Rev (2020) 19(7):102571

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Thus, while autophagy and mitophagy are essential homeostatic processes that protect cells from the accumulation of damaged cellular components, their excessive activation could be detrimental and causative of human diseases, as recently shown 68