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Therefore, only rats that were unresponsive lost their righting reflex and whose pupils were dilated during ischemia were selected to evaluate completed cerebral ischemia, as recommended by Pulsinelli (Pulsinelli et al

Knapp and Klann, 2002)

The structural alteration in APOE4 impairs its ability to bind and transport lipids (cholesterol, phospholipids) efficiently, compared to APOE3 and APOE2